Always run PLITCH with Admin rights and make sure that the entire PLITCH installation folder is whitelisted in your Antivirus.
If your windows user is not an administrator, you have to make sure that also all your game platforms (Steam, Origin, Epic, MS Store, UPlay, Gog or Retail) are running with admin-rights as well. Otherwise, PLITCH will not be able to find the game’s .exe – this mainly has to do with Microsoft’s weird user control ever since Windows Vista. So if your trainer just cannot recognize the game, double that everything was started as ADMIN.
Is Nvidia Shadowplay/Geforce experience blocking your ALT + F 1 -10 Hotkeys? You can disable Shadowplay in Geforce Experience, or change its hotkeys via ALT + Z - settings - hotkeys. You can also change the hotkeys for each game with the ‘edit-icon’ (pencil) next to each cheat.
My game and PLITCH are running but none of the cheats are activating?
